parenteral nutrition associated liver disease

The aim of this review is to provide an update of the epidemiology, pathophysiology, and diagnosis of
intestinal failure-associated liver disease in adults as well as to present a clinical approach of the therapeutic strategies of intestinal failure-associated liver disease and present novel therapeutic targets.

We will cover the current clinical studies on the benefit of fish oil and medium chain triglyceride
containing lipid emulsions on the development of parenteral nutrition associated cholestasis, the current constituents of lipid emulsions that may modulate the prevalence of parenteral nutrition associated cholestasis, and potential new supplements to total parenteral nutrition to further reduce the incidence of parenteral nutrition associated cholestasis.